Should we stop using tricyclic antidepressants in pregnancy?

Taking antidepressants during late pregnancy. How should we advise women?

QUESTION In light of recent negative media attention to antidepressant use during late pregnancy, several of my patients have either discontinued or are considering discontinuing their antidepressant medications. How can I best counsel these patients on taking antidepressants during late pregnancy? ANSWER Antidepressant use during the third trimester has been associated occasionally with a tr...

Tricyclic antidepressants.

Tricyclic antidepressants.

Correspondence BRiTISH 301 Tricyclic Antidepressants SIR,-I am worried by one sentence in the article on tricyclic antidepressants (13 April, p. 102): "Jaundice, which is very uncommon , is of the cholestatic type similar to that found in chlorpromazine." This is misleading. Jaundice is one of the more frequent side-effects reported from imipramine and imitrip-tyline, the most widely used membe...

Pharmacokinetics of Tricyclic Antidepressants

This review, together with Part 1 (Gun. Chem. 26: 5-17, 1980), summarizes progress in measurement of tricyclic antidepressants in biological fluids and the application of the methodology to Clinical practice. For many of the older drugs and for all of the new-generation antidepressants, further studies are required to delineate the precise relationship between plasma concentration and clinical ...

Editorial Atherosclerosis Should We Stop TWEAKing It ?

Atherosclerosis is a very complex pathology. Over the past two decades we have come to appreciate that a major component of this pathological process is chronic inflammation. This inflammatory state is not only characterized by infiltration of lipid laden macrophages, the hallmark cell of this disease, into the vascular wall, but also is characterized by the infiltration of a host of other infl...